血液凝固と肥満の関係

Nature Medicineから

Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation pp1490 - 1497
Leylla Badeanlou, Christian Furlan-Freguia, Guang Yang, Wolfram Ruf and Fahumiya Samad
doi:10.1038/nm.2461
Fahumiya Samad and her colleagues have shown that the serine protease tissue factor, a key regulator of coagulation, has a role in obesity and metabolic disease. They find that tissue factor signaling in adipocytes promotes obesity, whereas its signaling in adipose tissue macrophages promotes local inflammation and insulin resistance.

組織因子が肥満と肥満に伴うインスリン抵抗性を悪化させるという