筋肉からのインターロイキン６がGLP-1分泌を促進する

Nature Medicineから

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells pp1481 - 1489
Helga Ellingsgaard, Irina Hauselmann, Beat Schuler, Abdella M Habib, Laurie L Baggio, Daniel T Meier, Elisabeth Eppler, Karim Bouzakri, Stephan Wueest, Yannick D Muller, Ann Maria Kruse Hansen, Manfred Reinecke, Daniel Konrad, Max Gassmann, Frank Reimann, Philippe A Halban, Jesper Gromada, Daniel J Drucker, Fiona M Gribble, Jan A Ehses and Marc Y Donath
doi:10.1038/nm.2513
Helga Ellingsgaard et al. show that secretion of interleukin-6 by muscle in response to exercise, or injection of recombinant protein, increases the expression of the incretin GLP-1 by both intestinal cells and by pancreatic alpha cells, thus potentiating insulin release and improving glycemic control. These results identify a new endocrine loop linking energy demands to homeostatic control while also suggesting further targets for type 2 diabetes therapy.

インターロイキン６って炎症性のサイトカインだけどIL-6が出るくらいの運動ってどれくらいの強度なんだろうか？相撲取りの朝の稽古みたいなもんか？