More than RAGE
J Immunol. 2012 Mar 1;188(5):2380-6. Epub 2012 Jan 27.
The IKKα-dependent NF-κB p52/RelB noncanonical pathway is essential to sustain a CXCL12 autocrine loop in cells migrating in response to HMGB1.Kew RR
HMGB1 mediated cell migration;
well known: HMGB1->RAGE->IKKbeta->NFkB
alternatively, HMGB1->CXCL12->CXCR4->IKKalpha->p52/RelB